More information: Vittoria Borgonetti et al, Excessive alcohol intake produces persistent mechanical allodynia and ...

Burning to be thin? Dr. Daniel Rosen, a NYC-based surgeon and weight-loss doctor, has taken to TikTok to share the unusual ...

This previously unknown family of endogenous TRPV1 ligands and their related linoleic acid metabolites were potent activators of TRPV1 and could initiate the development of mechanical allodynia.

Allodynia may be due to a peripheral mechanism, reflecting an abnormal reduction of the mechanical threshold in sensitised nociceptors, or to a central mechanism, reflecting the sensitization of ...

Researchers from Vera Salus Ricerca Srl and affiliated organizations have reported the discovery and preclinical characterization of novel sigma-1 receptor (S1R) antagonists as potential new analgesic ...

The Company also performed a mechanical allodynia test in rodents with the same arms as above. For both models, the drugs were administered as a sciatic nerve block. All four Company formulations ...

Method Patients with unexplained CCAP in a tertiary neurogastroenterology clinic (2009–2016) were initially assessed for ‘clinical’ diagnoses of NP or NBS based on history and presence of cutaneous ...