Sildenafil citrate is a selective and potent inhibitor of phosphodiesterase type 5 (PDE5). PDE5 is a cyclic guanosine monophosphate (cGMP) specific degrading enzyme that is highly present in the ...

A total of 144 DUs (72 in each group) with a total number of events (DU healing) of 81 would ensure an 80% power to detect a difference between proportions of events P1 (placebo) of 0.30 and P2 ...