Antigenic stimulation mediated by the B-cell receptor (BCR) regulates survival, proliferation and migration processes in B-CLL, thus suggesting a prominent role in B-CLL pathogenesis and progression.

2. How can binding between antigen and the BCR be converted across the plasma membrane into chemical changes that initiate B cell signaling cascades? 3. How do co-receptors, lipid species, cortical ...

B cell receptor (BCR) signaling plays a fundamental role in B cell development, activation, and antibody responses. The BCR consists of a membrane immunoglobulin (mIg), the antigen recognition subunit ...

Now, Honigberg and colleagues describe an orally available, potent and selective inhibitor of the B-cell receptor (BCR) signalling molecule Bruton's tyrosine kinase (BTK), which shows promising ...

Talimogene laherparepvec (T-VEC) demonstrates efficacy in cutaneous BCC, enhancing resectability and altering immune cell ...

Figure 4: Impaired antigen receptor–activated B cell proliferation and humoral responses in Vav-deficient mice. Figure 5: Vav-2 in BCR signaling and tyrosine phosphorylation in Vav-1 −/− Vav ...

Superantigens are microbial toxins that interact with immune receptors of B lymphocytes (B cell receptors, BCR) outside the usual sites involved in the recognition of antigens e.g. complementary ...

In turn, B cell response is governed by recognizing an antigen to the B cell receptor (BCR). This recognition and subsequent response coordinate a series of transcriptional programs. Single-cell RNA ...

TCR and BCR kits, a family of multiplex-PCR, NGS-based assays that enable profiling of up to all seven T-cell receptor (TCR) and B-cell receptor (BCR) chains from the same sample, in a single tube, ...

Recent advancements in high-throughput sequencing technologies have significantly enhanced our ability to characterize B cell receptor (BCR) repertoires on a large scale. However, the sheer volume and ...

CD72 is a regulator of the B cell receptor (BCR) expressed mainly on B cells. B6/lpr CD72KO mice are a mouse model of lupus with a stronger phenotype than existing B6/lpr mice and can survive longer ...