The diagnosis is usually made by observing a concentric ring pattern on MRI; laboratory studies might help to exclude other etiologies. In uncertain cases, a biopsy can be performed to confirm the ...

Balò's concentric sclerosis is a rare demyelinating disease presenting with a concentric ring in the white matter. The clinical and radiological features can mimic other diseases such as primary ...

Figure 1 iNOS immunoreactivity (brown) in an acute MS lesion from a patient with Balo's concentric sclerosis. Reproduced with the permission of the American Society for Investigative Pathology 16 ...

including multiple sclerosis (MS), neuromyelitis optica (NMO), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), acute disseminated encephalomyelitis, and Balo's concentric ...