Arthritis Foundation3y
FDA Advisory Panel Recommends Softening “Celebrex” Safety Labeling
“Nonselective” NSAIDs, such as naproxen and ibuprofen, block both COX-1 and COX-2; by blocking COX-1, they give rise to gastrointestinal (GI) side ... 200 mg twice a day of celecoxib, 600 to 800 mg ...
gut.bmj2mon
Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen
Professor D Fitzgerald, Centre of Cardiovascular Science, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin, Ireland.dfitzgerald{at}rcsi.ie BACKGROUND Selective inhibitors of ...
BMJ9mon
A randomised, placebo controlled, comparative trial of the gastrointestinal safety and efficacy of AZD3582 versus naproxen in osteoarthritis
Methods: 970 patients were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily ... Both agents were well tolerated, with no significant effects on blood pressure. Conclusions ...