Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and young adults between the ages of 10 and 20, during times of rapid bone growth. Although rare, it has a ...

Large-scale analysis of patient cohorts reveals a novel mechanism driving osteosarcoma, an aggressive paediatric bone cancer. The researchers show that this mechanism occurs in approximately 50% of ...

After finally getting a MRI scan in December 2023 the devastating diagnosis was revealed: osteosarcoma. Doctors informed her that amputation was the only way to prevent the cancer from spreading.

Dr. Solange De Noon, co-first author of the study from UCL Cancer Institute and EMBL-EBI, said: "Our work to uncover a key biological mechanism that drives osteosarcoma and gain insight into how a ...

By analysing the largest collection of whole-genome data from osteosarcoma patients, the researchers identified a new mutation mechanism, called loss-translocation-amplification (LTA ...

Insights extend to other cancers, emphasizing the significance of genomic instability in cancer progression. Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and ...