Data from a large study of syphilis indicate a high rate of neurosyphilis in HIV-infected patients with a CD4-cell count less than or equal to 350 or a serum RPR titer greater than or equal to 1:32.

Clinical management of patients with early syphilis has been ... Follow-up relies on decline in serologic tests titers; management of patients who remain serofast is a point of clinical concern.

A new study published in the journal Nature provides compelling evidence that syphilis originated in the Americas and spread globally through European colonization, challenging long-held ...

at which time titers are expected to reduce fourfold. Treponemal tests are used to validate nontreponemal test results and to diagnose early syphilis infections that cannot (yet) be detected by ...