The pre-B-cell receptor (pre-BCR), which comprises two Igμ chains and two germline-encoded surrogate light chains (SLC) that are associated with the signalling subunits Igα and Igβ, is formed ...

Antigenic stimulation mediated by the B-cell receptor (BCR) regulates survival, proliferation and migration processes in B-CLL, thus suggesting a prominent role in B-CLL pathogenesis and progression.

Researchers determine a complex immune infiltrate pattern based on a newly constructed immune map developed using pancreatic ...

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, with disease progression ranging from slow and indolent to ...

Bcl-2: B-cell leukemia/lymphoma 2; BCR: B-cell receptor; CLL: Chronic lymphocytic leukemia; CXCL: CXC chemokine ligand; CXCR: CXC chemokine receptor; ERK: Extracellular signal-regulated kinase ...