Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

During the apprehension, a total of 800 clone bank cards were found in his possession including the cloning machine. More updates to follow.

Tuspetinib (TUS) is a well-tolerated, once daily, oral kinase inhibitor in clinical development for treatment of acute myeloid leukemia (AML). Nonclinical studies show that TUS targets key prosurvival ...

Therefore, it is necessary to accelerate the improvement of wheat quality through molecular marker-assisted analysis of quality genes and phenotype of quality traits. At present, the low-quality wheat ...

1 St-Patrick Research Group in Basic Oncology, Oncology Division, Centre Hospitalier Universitaire (CHU) de Québec-Université Laval Research Center, Québec, QC, Canada 2 Department of Molecular ...

Studying these questions is crucial for understanding molecular and cellular mechanisms, whose disruption can contribute to the onset and progression of various diseases. These are also key issues ...