Researchers from Vera Salus Ricerca Srl and affiliated organizations have reported the discovery and preclinical characterization of novel sigma-1 receptor (S1R) antagonists as potential new analgesic ...

A top NYC weight-loss doctor shared the surprising skin complication that he’s encountered in patients using GLP-1 drugs like ...

Allodynia may be due to a peripheral mechanism, reflecting an abnormal reduction of the mechanical threshold in sensitised nociceptors, or to a central mechanism, reflecting the sensitization of ...

Try gentler methods, like a cold washcloth, so you don't shock your system. You may also have to worry about mechanical allodynia, which is pain from something moving across the skin, and that can ...

Mechanical keyboards have gone from niche peripherals favored by enclaves of retro conservationists, coders, typists, and subversive eSports pros to a ubiquitous part of the mainstream PC gaming scene ...

HT-6184 is under development for the treatment of thermal hyperalgesia and mechanical allodynia, Alzheimer’s disease, myelodysplastic syndrome (MDS), chronic inflammation, acute myeloid leukemia (AML) ...

There is a planned Crossref maintenance outage between Tuesday, 14 January 6:00 to 11:00 UTC. This impacts access to BibTeX and RIS files. This important study leverages the power of Drosophila ...

Hyperpathia, hyperalgesia, and allodynia are three manifestations of central sensitization, a condition in which a higher than necessary degree of activity is triggered in the central nervous system.

The trials included a thermal hyperalgesia test and a mechanical allodynia test on rodents, with both tests showing that Channel's formulations had a depot effect lasting more than four days, ...

The Company also performed a mechanical allodynia test in rodents with the same arms as above. For both models, the drugs were administered as a sciatic nerve block. All four Company formulations ...