Unlike other chronic arthropathies we have good understanding of gout pathogenesis and have effective treatment strategies to eliminate the pathogenic agent (urate crystals) to effect a “cure”. This ...

If crystal removal from joints and tissues leads to the ... is the most commonly recommended serum uric acid (SUA) target level for gout patients. Lower levels (300 µmol/l) are included in ...

both in patients with serious crystal-related complications and also in the average gout patient; Find a practical and easy method to precisely assess the crystal burden of a patient, and whether ...

Objective Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, ...

Excess uric acid can produce uric acid crystals, which then build up in soft tissues and joints, causing the painful symptoms of gout. Dietary management focuses on reducing the amount of uric acid in ...

just as similar crystals elicit a gouty inflammatory cascade in synovial joints. Further studies are necessary to determine whether urate crystals may play this role in these tissues and, if so, to ...

Gout is an inflammatory type of arthritis that’s caused by crystal deposits that build up in joint. It can be confused for another condition that involves crystal build up. Learn how to recognize the ...

Gout develops from hyperuricemia—high urate levels in the body—which causes sharp crystals to build up in the joint.

Gout is a form of arthritis caused by a buildup of uric acid crystals in a joint. It causes sudden attacks of pain, swelling, redness, and stiffness, usually in one joint, especially the big toe. Gout ...

Objective To examine factors influencing the kinetics of monosodium urate (MSU) crystal dissolution measured with dual-energy computed tomography (DECT) during follow-up of patients with gout. Methods ...

Experimental models of gouty inflammation have shown that neutrophil influx in response to MSU crystals is reduced in mice deficient in inflammasome components or in the IL-1 receptor (IL1-R1 ...