Unlike other chronic arthropathies we have good understanding of gout pathogenesis and have effective treatment strategies to eliminate the pathogenic agent (urate crystals) to effect a “cure”. This ...

If crystal removal from joints and tissues leads to the ... is the most commonly recommended serum uric acid (SUA) target level for gout patients. Lower levels (300 µmol/l) are included in ...

Objective Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, ...

You may need surgery to remove large or very painful tophi ... Tophaceous gout is the most severe form of gout. Urate ...

just as similar crystals elicit a gouty inflammatory cascade in synovial joints. Further studies are necessary to determine whether urate crystals may play this role in these tissues and, if so, to ...

Gout is an inflammatory type of arthritis that’s caused by crystal deposits that build up in joint. It can be confused for another condition that involves crystal build up. Learn how to recognize the ...

Gout is one of the most severe and frequent rheumatic diseases. Clinical manifestations of gout arise from uric acid crystal deposition in the musculoskeletal tissue. At high concentrations of uric ...

Gout is no longer a disease of rich monarchs who overindulge in fatty meats and wine, but a health problem that can affect anyone. Foods rich in purines can raise blood levels of uric acid. Deposits ...

Having gout increases the risk of developing diabetes, heart disease and other conditions. In gout, uric acid builds up and forms painful crystals around joints, often affecting the big toe. Health ...

Gout is a form of arthritis caused by a buildup of uric acid crystals in a joint. It causes sudden attacks of pain, swelling, redness, and stiffness, usually in one joint, especially the big toe. Gout ...

Over time, this extra acid can form into tiny sharp crystals, which collect around your joints. A gout attack strikes when your body's immune system is triggered, often at night. White blood cells ...