Lysosome. appearance, exterior and interior view. Cross section and Anatomy of the Lysosome: Hydrolytic enzymes, Membrane and transport proteins. Vector illustration Anatomy of the Lysosome: ...

It is concluded that chronic ethanol consumption, in both protein sufficient and protein deficient states, increases the capacity of the pancreatic acinar cell to synthesise digestive and lysosomal ...

The fight against cancer often begins with uncovering hidden players, and this study reveals one such key player: an unexpected class of abbreviated N-glycans. These molecules, upregulated in cancer ...

In this manuscript, Yong and colleagues link perturbations in lysosomal lipid metabolism with the generation of protein aggregates resulting from proteosome inhibition. The main tool used is the ...

comprise a group of more than 40 diseases caused by a deficiency of lysosomal enzymes, membrane transporters or other proteins involved in lysosomal biology. The predominant inheritance pattern is ...

Lysosomes are organelles found within nearly all eukaryotic cells and are responsible for breaking down larger molecules such as proteins, fats and carbs. Lysosomal exocytosis occurs when the ...

Mechanistically, PI3K-C2γ recruits Asap1 to the lysosome to repress mTORC1 activation in response ... To analyse the incorporation of uniformly (U) radiolabeled 14 C-glutamine into proteins and lipids ...

HSC70 protein acts with a series of co-chaperones including Nag ... our studies show that a peptide that can modulate lysosomal degradation can be beneficial in MRL/lpr mice by reducing autoreactive T ...

Cathepsin D (CTSD) is a lysosomal protease important for the degradation of various substrates, including disease-associated proteins like α-synuclein (a-syn), amyloid precursor protein (APP) and tau, ...

This month's cover highlights the article Deep imaging reveals dynamics and signaling in one-to-one pollen tube guidance by Yoko Mizuta, Daigo Sakakibara, and colleagues. The image shows two-photon ...