“Something I’ve been seeing with my patients lately, a very few but a legitimate number of my patients, is allodynia,” Rosen ...

More information: Vittoria Borgonetti et al, Excessive alcohol intake produces persistent mechanical allodynia and ...

Allodynia may be due to a peripheral mechanism, reflecting an abnormal reduction of the mechanical threshold in sensitised nociceptors, or to a central mechanism, reflecting the sensitization of ...

This previously unknown family of endogenous TRPV1 ligands and their related linoleic acid metabolites were potent activators of TRPV1 and could initiate the development of mechanical allodynia.

Method Patients with unexplained CCAP in a tertiary neurogastroenterology clinic (2009–2016) were initially assessed for ‘clinical’ diagnoses of NP or NBS based on history and presence of cutaneous ...

Researchers from Vera Salus Ricerca Srl and affiliated organizations have reported the discovery and preclinical characterization of novel sigma-1 receptor (S1R) antagonists as potential new analgesic ...

The Company also performed a mechanical allodynia test in rodents with the same arms as above. For both models, the drugs were administered as a sciatic nerve block. All four Company formulations ...