The observation that tamoxifen acts as an antioestrogen on the breast but has paradoxical oestrogenic effects on bones and lipids heralded the development of the selective oestrogen-receptor ...

In this clinical trial, 4742 postmenopausal women in 37 countries who had received initial treatment for unilateral estrogen-receptor-positive breast cancer and had been taking adjuvant tamoxifen ...

Figure 1 Histological sections of tamoxifen-resistant T47D breast tumours stained for ... Figure 3 Divergence points that a SERM must pass to modulate oestrogen-like actions in a target tissue. A SERM ...

To compound matters, tamoxifen is a two-edged sword ... co-regulators modulate the transcriptional potential of estrogen receptor activated by estradiol, SERMs or growth factors.

Background: Tamoxifen (Tam) is used for the treatment and prevention of estrogen-receptor-positive human breast and other cancers. Its use in ovarian cancer has not been well studied. Method ...

Maintaining tamoxifen sensitivity is keyTamoxifen is an effective breast cancer treatment for patients who are estrogen receptor positive – the majority of breast cancer patients. Breast cancer ...

Tamoxifen is a non-steroidal selective oestrogen receptor modulator commonly used in the treatment of breast cancer. It is associated with the development of fatty liver and steatohepatitis however ...

Study says there is evidence of a statistically significant survival benefit from adjuvant tamoxifen among patients with estrogen receptor (ER)-positive tumors A brief communication published ...

Considering taking medication to treat hormone receptor positive postmenopausal early breast cancer after adjuvant tamoxifen? Below is a list of common medications used to treat or reduce the ...

Breast Cancer,Cancer Cells,Conventional Treatment,Dose Of Tamoxifen,Drug Delivery Efficacy,Electric Field Strength,Electrostatic Potential,Energy Production,Estrogen Receptor,Estrogen Receptor ...

Here we describe a murine model with tamoxifen-inducible fibroblast-specific deletion of the IL-1 receptor (IL1R1) for assessing the importance of the IL-1/CF axis in vivo. Methods IL1R1-/- mice and ...